Pre-exposure prophylaxis and antiretroviral treatment interventions with drug resistance

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• 作者：Komi Afassinou ; ^a ; ^b ; ^{komia@aims.ac.za} ; Faraimunashe Chirove^a ; ^{chirovef@ukzn.ac.za} ; Keshlan S. Govinder^a ; ^{govinder@ukzn.ac.za}
• 关键词：Prep drug resistance ; Prep awareness ; Prep efficacy
• 刊名：Mathematical Biosciences
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：285
• 期：Complete
• 页码：92-101
• 全文大小：1072 K
• 卷排序：285

文摘

Introduction of a mathematical model for the spread of HIV incorporating both PrEP use for HIV prevention and ARV use for HIV treatment. Either PrEP or ARV use as a single intervention strategy was found to be inadequate in sustainably reducing the spread of HIV. A combination of both interventions, at high levels, offers the best potential for significant reduction of new HIV infections. The PrEP efficacy level was found to be a key control factor for effective reduction of HIV incidence. PrEP drug resistance could be one of the key drivers of HIV spread.