Effective G-protein coupling of Y2 receptors along axonal fiber tracts and its relevance for epilepsy

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• 作者：Elisabeth Dum¹ ; ^{dum.elisabeth@gmail.com} ; Sabine Fü ; rtinger² ; ^{sabine.fuertinger@gmx.at} ; Elisabeth Gasser ; Anneliese Bukovac ; Meinrad Drexel ; Ramon Tasan ; Gü ; nther Sperk ; ^{guenther.sperk@i-med.ac.at}
• 关键词：NPY ; Y2 receptors ; Schaffer collaterals ; Stria terminalis ; GTPγS ; G-protein coupling ; Kainic acid ; Epilepsy
• 刊名：Neuropeptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：61
• 期：Complete
• 页码：49-55
• 全文大小：1385 K
• 卷排序：61

文摘

NPY-Y2 receptors are expressed along fiber tracts. Y2 specific receptor binding is inhibited by GTPγS. Y2 receptor binding is functionally coupled to G-proteins. Y2 specific receptor binding is enhanced after strong seizures. Y2 binding is more sensitive to GTPγS after seizures.