IL-17 signalling in astrocytes promotes glutamate excitotoxicity: Indications for the link between inflammatory and neurodegenerative events in multiple sclerosis

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• 作者：Milos Kostic^a ; ^{milosh.kostic@hotmail.com} ; Nikola Zivkovic^b ; Ana Cvetanovic^c ; Ivana Stojanovic^d ; Miodrag Colic^a
• 关键词：IL-17A ; Multiple sclerosis ; Astrocyte ; Glutamate transporter ; Glutamine synthetase ; Glutamate exocytosis ; Glutamate excitotoxicity
• 刊名：Multiple Sclerosis and Related Disorders
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：11
• 期：Complete
• 页码：12-17
• 全文大小：742 K
• 卷排序：11

文摘

IL-17A down-regulates glutamate transporter expression in astrocytes. IL-17A down-regulates glutamine synthetase expression in astrocytes. IL-17A stimulates Ca2+ dependent glutamate release in astrocytes.