Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory

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• 作者：D. Lana^a ; J. Di Russo^b ; T. Mello^c ; G.L. Wenk^d ; M.G. Giovannini^a ; ^{mariagrazia.giovannini@unifi.it}
• 关键词：ACQ ; acquisition ; ACh ; acetylcholine ; DMSO ; dimethyl sulfoxide ; IA ; inhibitory avoidance ; i.c.v. ; intracerebroventricular ; i.p. ; intraperitoneal ; mTOR ; mammalian Target of Rapamycin ; mAChR ; muscarinic acetylcholine receptors ; mTORC1 ; 2 ; mammalian Target of Rapamycin Complex 1 ; 2 ; MEC ; mecamylamine ; nAChR ; nicotinic acetylcholine receptors ; p70S6K ; p70S6Kinase ; P-mTOR ; phospho-mTOR ; P-p70S6K ; phospho-p70S6K ; RAPA ; rapamycin ; SCOP ; scopolamine ; SEM ; standard error of the mean
• 刊名：Neurobiology of Learning and Memory
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：15-26
• 全文大小：2339 K
• 卷排序：137

文摘

mTOR/p70S6K activation in area CA3 are involved in long term memory formation. Rapamycin inhibited mTOR/p70S6K activation at 4 h and impaired long term memory at 24 h. Scopolamine activated mTOR/p70S6K at 1 h and impaired short but not long term memory. Mecamylamine reduced the scopolamine-induced increase of mTOR/p70S6K activation at 1 h. Rapamycin increased mTORC2 activation in microglial cells in Stratum Radiatum.