Protective effects of a herbal extract combination of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein

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• 作者：Yeomoon Sim^a ; Gunhyuk Park^a ; Hyeyoon Eo^b ; Eugene Huh^b ; ^c ; Pil Sung Gu^b ; Seon-Pyo Hong^b ; Youngmi Kim Pak^d ; Myung Sook Oh^a ; ^b ; ^{msohok@khu.ac.kr}
• 关键词：6-OHDA ; 6-hydroxydopamine ; DAT ; dopamine transporter ; ERK ; extracellular signal-regulated kinase ; HPLC ; high-performance liquid chromatography ; MABH ; herbal extract combination of Bupleuri Radix ; Moutan Cortex Radicis and Angelica Dahuricae Radix ; MPTP ; 1-methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; Nurr1 ; nuclear receptor-related 1 protein ; PBS ; phosphate-buffered saline ; PD ; Parkinson&rsquo ; s disease ; ROP ; ropinirole ; SNpc ; substantia nigra pars compacta ; ST ; striatum ; TH ; tyrosine hydroxylase
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：166-175
• 全文大小：1529 K
• 卷排序：340

文摘

MABH improved MPTP-induced movement impairments in mice. MABH prevented dopamine depletion and protected against MPTP-induced dopaminergic neuron damage in mice. MABH increased Nurr1 expression in the SNpc of mice. MABH increased TH, DAT, and VMAT2 expressions by upregulating Nurr1 via phosphorylation of ERK in PC12 cells.