Involvement of Wnt pathway in ethanol-induced inhibition of mouse embryonic stem cell differentiation

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• 作者：Qian Wang^a ; ¹ ; Jing-wen Song^a ; ¹ ; Yang Liu^b ; Xian-xian Zhao^a ; ^{chxnkwq@outlook.com}
• 关键词：Ethanol ; Embryonic stem cells ; Differentiation ; Wnt
• 刊名：Alcohol
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：58
• 期：Complete
• 页码：13-18
• 全文大小：1389 K
• 卷排序：58

文摘

Ethanol induced growth inhibition in ESCs after 5 days exposure. Ethanol delayed cardiac differentiation of ESCs till 11 days differentiation. Ethanol time/dose-dependently inhibited the loss of pluripotent gene expressions. Expressions of cardiac markers were suppressed with ethanol treatment. Expressions of Wnt-related regulators were downregulated by ethanol.