Curcumin inhibits glial scar formation by suppressing astrocyte-induced inflammation and fibrosis in vitro and in vivo

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• 作者：Jichao Yuan ^{531014699@qq.com} ; Wei Liu ^{woshiliuwei2012@sina.com} ; Haitao Zhu ^{woshihaitao2012@sina.com} ; Yaxing Chen ^{yaxingchensyd@sina.com} ; Xuan Zhang ^{504993085@qq.com} ; Lan Li ^{woshililan2015@sina.com} ; Weihua Chu ^{chuweihua2015@sina.com} ; Zexian Wen ^{wenzexiansyd@sina.com} ; Hua Feng ^{496017714@qq.com} ; Jiangkai Lin ; ^{jklin@tmmu.edu.cn}
• 关键词：Curcumin ; NF-κb ; SOX9 ; Glial scar ; Dual-target therapy
• 刊名：Brain Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：1655
• 期：Complete
• 页码：90-103
• 全文大小：3088 K
• 卷排序：1655

文摘

Cur reduces infiltrations of chemokine-induced macrophage and T-cells via the NF-κb pathway. Cur suppresses astrocyte α-SMA expression via the SOX9 pathway. Cur possesses simultaneous anti-inflammatory and anti-fibrotic functions. Cur inhibits intra- and extra-cellular components of glial scars via its dual effects.