Paternal deprivation affects social behaviors and neurochemical systems in the offspring of socially monogamous prairie voles

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• 作者：Manal Tabbaa ; Kelly Lei ; Yan Liu ; Zuoxin Wang ; ^{zwang@psy.fsu.edu}
• 关键词：BDNF ; brain-derived neurotrophic factor ; CRH ; corticotrophin releasing hormone ; CRHR1 ; corticotrophin releasing hormone receptor 1 ; CRHR2 ; corticotrophin releasing hormone receptor 2 ; EPM ; elevated plus maze ; fMRI ; functional magnetic resonance imaging ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; GR ; glucocorticoid receptor ; GRα ; glucocorticoid receptor alpha ; GRβ ; glucocorticoid receptor beta ; H3ace ; histone 3 acetylation ; H3K9ace ; histone 3 acetylation at lysine 9 ; H3total ; total histone
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：343
• 期：Complete
• 页码：284-297
• 全文大小：1046 K
• 卷排序：343

文摘

Pups raised by both parents (MF) received more parental care than ones raised by mothers only (MO). Paternal deprivation (PD) during early development led to an increase in social affiliation. PD experience was associated with enhanced BDNF, TrkB, H3, and H3ace protein expression in the hippocampus. PD experience also affected hippocampal GRβ, OTR, and CRHR2 protein expression in a sex-specific manner. Altered neurochemical expression in the hippocampus may mediate social affiliation.