Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity

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• 作者：Maria Keller¹ ; Lydia Hopp² ; Xuanshi Liu¹ ; ³ ; Tobias Wohland¹ ; Kerstin Rohde¹ ; Raffaella Cancello⁴ ; Matthias Klö ; s¹ ; Karl Bacos⁵ ; Matthias Kern⁶ ; Fabian Eichelmann¹ ; Arne Dietrich¹ ; ⁷ ; Michael R. Schö ; n⁸ ; Daniel Gä ; rtner⁸ ; Tobias Lohmann⁹ ; Miriam Dreß ; ler⁹ ; Michael Stumvoll¹ ; ⁶ ; Peter Kovacs¹ ; Anna-Maria DiBlasio⁴ ; Charlotte Ling⁵ ; Hans Binder² ; Matthias Bl&uuml ; her¹ ; ⁶ ; ^{matthias.blueher@medizin.uni-leipzig.de} ; Yvonne Bö ; ttcher¹ ; ¹⁰ ; ^{yvonne.boettcher@medizin.uni-leipzig.de} ; ^{yvonne.bottcher@medisin.uio.no}
• 关键词：DNA methylation ; Epigenetic mechanisms ; Human adipose tissue depots ; mRNA expression ; Obesity-related co-morbidities
• 刊名：Molecular Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：6
• 期：1
• 页码：86-100
• 全文大小：2476 K
• 卷排序：6

文摘

Obesity-associated differences in DNA promoter methylation and transcriptome in human adipose tissue (ETV6). Depot-specific analyses revealed novel/known genes (HAND2, HOXC6, PPARG, SORBS2, CD36, CLDN1). EWAS revealed SSPN and CCDC125 associated to BMI in SAT or OVAT, respectively. Differentially methylated genes overlap in part with GWAS hits for obesity and fat distribution.