Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode

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• 作者：Jordan M. Sorokin¹ ; ² ; Thomas J. Davidson³ ; Eric Frechette² ; Armen M. Abramian² ; Karl Deisseroth⁴ ; John R. Huguenard² ; Jeanne T. Paz⁵ ; ⁶ ; ⁷ ; ^{jeanne.paz@gladstone.ucsf.edu}
• 关键词：epilepsy ; thalamocortical ; optogenetics ; closed-loop ; electrophysiology ; oscillations ; SSFO ; bursts
• 刊名：Neuron
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：93
• 期：1
• 页码：194-210
• 全文大小：6524 K
• 卷排序：93

文摘

TC output is synchronized, phasic, and rhythmic during spontaneous SWDs Unilaterally toggling TC phasic spiking via eNpHR induces bilateral SWDs Unilaterally toggling TC tonic spiking via SSFO bilaterally aborts SWDs Unilaterally suppressing TC output via eNpHR bilaterally shortens SWDs