The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor

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• 作者：Alla Khodorova^a ; Grant D. Nicol^b ; Gary Strichartz^a ; ^{gstrichartz@partners.org}
• 关键词：aPKC ; atypical protein kinase C ; C2-ceramide ; N-acetyl-D-sphingosine ; CLP ; contralateral paw ; IgG ; immunoglobin ; NGF ; nerve growth factor ; nSMase ; neutral sphingomyelinase ; p75NTR ; p75 neurotrophin receptor ; PBS ; phosphate buffered saline ; PI3K ; phosphatidyl inositol 3 kinase ; PKMζ ; protein kinase M zeta ; PWL ; paw withdrawal latency ; S1P ; sphingosine 1-phosphate ; S1PR ; sphingosine 1-phosphate receptor ; SphK ; sphingosine kinase ; TrkA ; tropomyosin receptor kinase A ; TRPV1 ; transient receptor poten
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：384-397
• 全文大小：748 K
• 卷排序：340

文摘

NGF sensitizes rat paw skin to thermal and to mechanical stimulation by separate pathways. Thermal sensitization is triggered via TrkA and mechanical by p75NTR. More distal downstream segments of these receptors show evidence of cross-modulation. Atypical PKCs, e.g., PKMζ, are essential for sensitization to both heat and to touch. The thermo-sensitive TRPV1 receptor also contributes to acute thermal hypersensitivity.