KLF7-transfected Schwann cell graft transplantation promotes sciatic nerve regeneration

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• 作者：Ying Wang^a ; Wen-yuan Li^a ; ^{yingwang770224@163.com} ; Hua Jia^b ; Feng-guo Zhai^c ; Wen-rui Qu^d ; Yong-xia Cheng^e ; Yan-cui Liu^a ; Ling-Xiao Deng^f ; Su-fen Guo^d ; Zai-shun Jin^d
• 关键词：AAV2 ; adeno-associated virus 2 ; ANA ; acellular nerve allograft ; CGRP ; calcitonin gene-related peptide ; ChAT ; choline acetyltransferase ; CMAP ; compound action potential amplitude ; CNS ; central nervous system ; CTB ; cholera toxin B ; d ; day ; DRG ; dorsal root ganglia ; EdU ; 5-ethynyl-2-deoxyuridine ; GAP43 ; growth-associated protein ; HRP ; Horseradish peroxidase ; KLF7 ; Kr&uuml ; ppel-like Factor 7 ; NF ; neurofilaments ; NGF ; nerve growth factor ; P0 ; peripheral myelin protein zero ; SCs ; Schwann cell ; SFI ; sc
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：319-332
• 全文大小：4710 K
• 卷排序：340

文摘

AAV2-KLF7 efficiently transduced KLF7 to SCs. KLF7-SCs promote Schwann cells proliferation and neurites outgrowth of DRG explants. The expression of KLF7 target genes were enhanced in SCs overexpressing KLF7. KLF7-SCs enhance motor and sensory axonal regeneration which resulted in motor functional recovery.