Systemic cisplatin exposure during infancy and adolescence causes impaired cognitive function in adulthood

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• 作者：Tami John^a ; ^{tamidjohn@gmail.com} ; ^{tdjohn@texaschildrens.org} ; Naomi Lomeli^b ; ^{nrlomeli@uci.edu} ; Daniela A. Bota^c ; ^{dbota@uci.edu}
• 关键词：Cisplatin (CDDP) ; Chemotherapy-related cognitive impairment (CRCI) ; Memory ; Pediatric
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：319
• 期：Complete
• 页码：200-206
• 全文大小：940 K
• 卷排序：319

文摘

A pediatric rodent model for chronic cisplatin-related cognitive impairment is proposed. Extent of cognitive impairment in the chemotherapy exposed pediatric rodent population appears to vary based on age of exposure and neurodevelopmental stage. Rats exposed to cisplatin during infancy show hippocampal-dependent cognitive impairment. Rats exposed to cisplatin during adolescence show more global cognitive deficits.