Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals

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• 作者：Yasmin Zakiniaeiz^a ; ¹ ; ^{yasmin.zakiniaeiz@yale.ed} ; Dustin Scheinost^b ; ¹ ; ^{dustin.scheinost@yale.edu} ; Dongju Seo^c ; ^{dongju.seo@yale.edu} ; Rajita Sinha^c ; ^{rajita.sinha@yale.edu} ; R. Todd Constable^a ; ^b ; ^d ; ^{todd.constable@yale.edu}
• 关键词：Addiction ; Alcohol dependence ; Cingulate cortex ; Cue reactivity ; Functional connectivity ; Relapse
• 刊名：NeuroImage: Clinical
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：13
• 期：Complete
• 页码：181-187
• 全文大小：902 K
• 卷排序：13

文摘

AUD patients showed blunted cingulate connectivity to alcohol and stress cues. Cingulate connectivity predicted time to relapse in AUD patients. Greater PCC connectivity during alcohol cues predicted longer time to relapse. AUD vs. HC subjects showed less cingulate connectivity to alcohol and stress cues. The cingulate cortex emerged as a marker of subsequent alcohol relapse.