Impaired function of α2-containing nicotinic acetylcholine receptors on oriens-lacunosum moleculare cells causes hippocampus-dependent memory impairments

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• 作者：Elise Kleeman¹ ; Sakura Nakauchi¹ ; Hailing Su ; Richard Dang ; Marcelo A. Wood ; Katumi Sumikawa ; ^{ksumikaw@uci.edu}
• 关键词：Nicotine exposure ; Object location memory ; Object recognition memory ; Schaffer collateral pathway ; Long-term potentiation
• 刊名：Neurobiology of Learning and Memory
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：136
• 期：Complete
• 页码：13-20
• 全文大小：999 K
• 卷排序：136

文摘

α2KO mice have impaired hippocampus-dependent memory. Maternal-nicotine-exposed α2KO mice do not show increased CA1 network excitation. Maternal-nicotine-treated α2KO mice do not have facilitated induction of LTP.