Synaptic changes in the hippocampus of adolescent female rodents associated with resilience to anxiety and suppression of food restriction-evoked hyperactivity in an animal model for anorexia nervosa

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• 作者：Chiye Aoki ^ca3@nyu.edu ; Tara G. Chowdhury ; Gauri S. Wable ; Yi-Wen Chen
• 关键词：ABA ; activity-based anorexia ; AN ; anorexia nervosa ; CON ; control ; EX ; exercise ; FR ; food restriction ; GABA ; gamma-aminobutyric acid ; GAD ; glutamic acid decarboxylase ; LTP ; long-term potentiation ; MWM ; Morris water maze ; Rm ; membrane resistance ; SR ; stratum radiatum ; SLM ; stratum lacunosum-moleculare ; THP ; 3α ; 5α[β]-tetrahydroprogesterone ; Rs ; receptors ; Vm ; membrane potential
• 刊名：Brain Research
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：1654
• 期：part_PB
• 页码：102-115
• 全文大小：2783 K
• 卷排序：1654

文摘

The hippocampus exhibits growth spurts during adolescence. 4 days of food restriction during adolescence alters hippocampal dendritic arbors. 8 days of exercise during adolescence alters hippocampal dendritic arbors. Activity-based anorexia is accompanied by synaptic changes in the hippocampus. α4βδ-GABAARs in the hippocampus dampen food restriction-evoked hyperactivity.