Effects of the GluN2B-NMDA receptor antagonist Ro 25-6981 on two types of behavioral flexibility in rats

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• 作者：Emma Clark^a ; Kristen Antoniak^a ; Alyssandra Feniquito^a ; Hans C. Dringenberg^a ; ^b ; ^{dringenb@queensu.ca}
• 关键词：N-methyl-d-aspartate receptors ; GluN2B subunit ; Water maze ; Reversal learning ; Spatial strategy ; Motor strategy ; Set-shifting ; Rat
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：319
• 期：Complete
• 页码：225-233
• 全文大小：1519 K
• 卷排序：319

文摘

GluN2 B antagonist impairs spatial reveal learning. A water maze-based set-shifting task is described. GluN2 B antagonist does not impair set-shifting. GluN2 B subunits participate in some, but not all forms of behavioral flexibility.