Estimation of radiation dosimetry for ⁶⁸Ga-HBED-CC (PSMA-11) in patients with suspected recurrence of prostate cancer

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• 作者：Mark A. Green^a ; Jacob A. Eitel^a ; James W. Fletcher^a ; ^{jwfletch@iupui.edu} ; Carla J. Mathias^a ; Mark A. Tann^a ; Thomas Gardner^b ; Michael O. Koch^b ; Wendy Territo^a ; Heather Polson^a ; Gary D. Hutchins^a
• 关键词：68Ga-HBED-CC (PSMA-11) ; PSMA-targeted PET/CT ; Prostate cancer recurrence ; Dosimetry ; 68Ga-DKFZ-PSMA-11 ; Glu-NH-CO-NH-Lys-(Ahx)-[68Ga(HBED-CC)]
• 刊名：Nuclear Medicine and Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：46
• 期：Complete
• 页码：32-35
• 全文大小：475 K
• 卷排序：46

文摘

This study was performed to estimate the human radiation dosimetry for [68Ga]Ga-HBED-CC (PSMA-11) (68Ga PSMA-11).MethodsUnder an RDRC-approved research protocol, we evaluated the biodistribution and pharmacokinetics of 68Ga PSMA-11 with serial PET imaging following intravenous administration to nine prostate cancer patients in whom clinical [11C]acetate PET/CT exams had been independently performed under Expanded Access IND 118,204. List-mode imaging was performed over the initial 0–10 min post-injection with the pelvis in the field-of-view. Whole-body images were acquired, pelvis-to-head, at 15, 60, and 90-min post-injection. Additional images of the pelvis were acquired at 40-min and 115-min, and voided urine collected from each subject at 48-min and 120-min post-injection. Radiation dosimetry estimates were calculated from these data using the OLINDA software package.ResultsRenal uptake was high and relatively invariant, ranging from 11% to 14% of the injected dose between 15 and 90-min post-injection. Radioactivity collected in the voided urine accounted for 14% of the injected dose over a period of 120-min. Lymph nodes and skeletal metastases suspicious for prostate cancer recurrence were detected in a greater number of patients using 68Ga PSMA-11 than using 11C-acetate.ConclusionKidneys are the critical organ following 68Ga PSMA-11 administration, receiving an estimated dose of 0.413 mGy/MBq.Advances in knowledge and implications for patient careThis study confirms that the kidneys will be the critical organ following intravenous administration of 68Ga PSMA-11, and provided data consistent with the expectation that 68Ga PSMA-11 will be superior to [11C]acetate for defining sites of recurrence in prostate cancer patients presenting with biochemical relapse.