Intra-LC microinjection of orexin type-1 receptor antagonist SB-334867 attenuates the expression of glutamate-induced opiate withdrawal like signs during the active phase in rats

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• 作者：Bita Hooshmand^a ; Hossein Azizi^a ; Mohammad Javan^a ; Saeed Semnanian^a ; ^b ; ^{ssemnan@modares.ac.ir}
• 关键词：Orexin-A ; Locus coeruleus ; Glutamate ; Circadian rhythm ; Morphine withdrawal signs
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：636
• 期：Complete
• 页码：276-281
• 全文大小：1808 K
• 卷排序：636

文摘

Intra-LC glutamate microinjection induces the expression of opiate withdrawal-like behaviors. SB-334867 did not affect glutamate-induced withdrawal-like signs during the rest phase. SB-334867 attenuated glutamate-induced withdrawal-like signs during the active phase.