Adrenergic Gate Release for Spike Timing-Dependent Synaptic Potentiation

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• 作者：Yanling Liu¹ ; Lei Cui¹ ; ² ; ³ ; Martin K. Schwarz⁴ ; Yan Dong⁵ ; Oliver M. Schlü ; ter¹ ; ² ; ⁵ ; ⁶ ; ^{schluter@pitt.edu}
• 关键词：spike timing-dependent plasticity ; SAP97 ; Kv1.1 ; β-adrenoceptor ; dendritic excitability ; signaling scaffold ; hippocampus
• 刊名：Neuron
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：93
• 期：2
• 页码：394-408
• 全文大小：5690 K
• 卷排序：93

文摘

Kv1.1 mediates dendritic potassium current in hippocampal neurons Kv1.1 gates spike timing-dependent LTP at hippocampal synapses SAP97 enables β2-adrenoceptor-induced inhibition of dendritic Kv1.1 SAP97/β2/Kv1.1-mediated regulation of dendrite excitability gates LTP