Melatonin-loaded silica coated with hydroxypropyl methylcellulose phthalate for enhanced oral bioavailability: Preparation, and in vitro-in vivo evaluation

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• 作者：Yuanyuan Li ; Xiuhua Zhao<sup> ; sup><sup>xiuhuazhao@nefu.edu.cnsup> ; Yuangang Zu ; Lingling Wang ; Weiwei Wu ; Yiping Deng ; Chang Zu ; Yanjie Liu
• 关键词：Melatonin ; Silica ; Enteric nanospheres ; Controlled release ; Solubility ; Bioavailability
• 刊名：European Journal of Pharmaceutics and Biopharmaceutics
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：112
• 期：Complete
• 页码：58-66
• 全文大小：839 K
• 卷排序：112

文摘

The silica loaded with melatonin, and then coated with HP55. The release of melatonin was markedly increased in vitro study. The bioavailability of MLT-SiO2-HP55 was 3.5 times as raw melatonin.