Does medial temporal lobe thickness mediate the association between risk factor burden and memory performance in middle-aged or older adults with metabolic syndrome?

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• 作者：Elissa C. McIntosh^a ; Aaron Jacobson^a ; Nobuko Kemmotsu^b ; Ekarin Pongpipat^a ; Erin Green^a ; ^c ; ¹ ; Lori Haase^b ; ^c ; Claire Murphy^a ; ^b ; ^c ; ^{cmurphy@mail.sdsu.edu}
• 关键词：Metabolic syndrome ; Medial temporal lobe ; Entorhinal cortical thickness ; MRI ; Memory
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：636
• 期：Complete
• 页码：225-232
• 全文大小：900 K
• 卷排序：636

文摘

The metabolic syndrome group had less cortical thickness in medial temporal lobe regions. Cortical thickness differences were most pronounced in the left entorhinal cortex. Cortical thickness mediated the association between risk factor burden and memory in middle age. Differences in middle age and older adults contribute to an understanding of these relationships.