The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis

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• 作者：Cheryl Cero¹ ; Maria Razzoli¹ ; Ruijun Han¹ ; Bhavani Shankar Sahu¹ ; Jessica Patricelli¹ ; ZengKui Guo³ ; Nathan A. Zaidman¹ ; John M. Miles³ ; Scott M. O'Grady² ; Alessandro Bartolomucci¹ ; ^{abartolo@umn.edu}
• 关键词：Adipocyte ; Complement 3a receptor ; Ca2+ ; MAPK/ERK ; β-AR ; Isoproterenol ; VGF
• 刊名：Molecular Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：6
• 期：1
• 页码：148-158
• 全文大小：1832 K
• 卷排序：6

文摘

TLQP-21/C3aR1 does not possess lipolytic properties per se. TLQP-21 enhances β-AR-induced lipolysis by a mechanism requiring Ca2+ mobilization and ERK activation of HSL. TLQP-21 acutely potentiated isoproterenol-induced lipolysis in vivo. TLQP-21 treatment decreases body weight and fat mass in DIO mice by a mechanism involving β-AR and C3aR activation. TLQP-21 anti-obesity effect is not associated with adverse metabolic effects.