Targeted drug delivery of Sunitinib Malate to tumor blood vessels by cRGD-chiotosan-gold nanoparticles

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• 作者：Mohaddeseh Mahmoudi Saber^a ; Sara Bahrainian^b ; Rassoul Dinarvand^a ; ^b ; Fatemeh Atyabi^a ; ^b ; ^{atyabifa@tums.ac.ir}
• 关键词：Cyclo(-RGDfK) (PubChem CID ; 10196873) ; Chitosan (PubChem CID ; 71853) ; Sunitinib malate (PubChem CID ; 6456015) ; Tetrachloroauric acid (PubChem CID ; 10925836) ; Trisodium citrate (PubChem CID ; 6224) ; SPDP (PubChem CID ; 157808) ; Fluorescein isothiocyanate (PubChem CID ; 18730) ; DAPI (PubChem CID ; 2954) ; Formaldehyde (PubChem CID ; 712) ; Dimethyl sulfoxide (PubChem CID ; 679)
• 刊名：International Journal of Pharmaceutics
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：517
• 期：1-2
• 页码：269-278
• 全文大小：2161 K
• 卷排序：517

文摘

The unique characteristics of tumor vasculature represent an attractive strategy for targeted delivery of antitumor and antiangiogenic agents to the tumor. The purpose of this study was to prepare c(RGDfK) labeled chitosan capped gold nanoparticles [cRGD(CS-Au) NPs] as a carrier for selective intracellular delivery of Sunitinib Malate (STB) to the tumor vasculature. cRGD(CS-Au) NPs was formed by electrostatic interaction between cationic CS and anionic AuNPs. cRGD modified CS-Au NPs had a spherical shape with a narrow size distribution. The entrapment efficiency of sunitinib molecule was found to be 45.2% ± 2.05. Confocal microscopy showed enhanced and selective uptake of cRGD(CS-Au) NPs into MCF-7 and HUVEC cells compared with non-targeted CS-Au NPs. Our results suggest that it may be possible to use cRGD(CS-Au) NPs as a carrier for delivery of anticancer drugs, genes and biomolecules for inhibiting tumor vasculature.