Regulation of brown and beige fat by microRNAs

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• 作者：Yong Chen¹ ; Ruping Pan² ; Alexander Pfeifer ; ^{alexander.pfeifer@uni-bonn.de}
• 关键词：ADAM17 ; ADAM metallopeptidase domain 17 ; ADINR ; adipogenic differentiation induced noncoding RNA ; ADNCR ; adipocyte differentiation-associated long noncoding RNA ; AMPK ; AMP-activated protein kinase ; aP2 ; fatty-acid binding protein 4 ; BAT ; brown adipose tissue ; Blnc1 ; brown fat lncRNA 1 ; BMI ; body mass index ; BMP7 ; bone morphogenetic protein 7 ; BMPR1A ; bone morphogenetic protein receptor-1α ; C/EBP ; CCAAT/enhancer-binding protein ; cGMP ; cyclic GMP ; Cidea ; cell death-inducing DNA fragmentation facto
• 刊名：Pharmacology & Therapeutics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：170
• 期：Complete
• 页码：1-7
• 全文大小：582 K
• 卷排序：170

文摘

MicroRNAs (miRNAs) are small non-coding RNA molecules consisting of approximately 20 to 22 nucleotides. They play a very important role in the regulation of gene expression. miRNAs can be found in different species and a variety of organs and tissues including adipose tissue. There are two types of adipose tissue in mammals: White adipose tissue (WAT) is the largest energy storage, whereas brown adipose tissue (BAT) dissipates energy to maintain body temperature. BAT was first identified in hibernating animals and newborns as a defense against cold. Later on, it was also discovered in human adults, suggesting its potential role in energy balance and metabolism. Moreover, “brown-like” adipocytes present in WAT depots, so called beige or brite (brown-in-white) cells, were discovered by several groups. In recent years, miRNAs were found to have important regulatory function during brown fat differentiation, brown fat activation and white fat “browning”. In this review, we focus on the regulation of brown and beige fat by miRNAs including the role in their differentiation and function, providing evidence for their therapeutic potential in metabolic diseases.