Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice

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• 作者：Mingke Song^a ; ¹ ; ² ; Shan Ping Yu^a ; ^b ; ¹ ; ^{spyu@emory.edu} ; Osama Mohamad^a ; Wenyuan Cao^a ; Zheng Zachory Wei^a ; Xiaohuan Gu^a ; Michael Qize Jiang^a ; Ling Wei^a ; ^{lwei7@emory.edu}
• 关键词：SVZ neurogenesis ; Striatum stimulation ; Optogenetics ; Glutamatergic neurons ; Ischemic stroke ; Semi-phasic synaptic regulation ; Functional recovery
• 刊名：Neurobiology of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：98
• 期：Complete
• 页码：9-24
• 全文大小：3700 K
• 卷排序：98

文摘

Glutamatergic neurons and axons in the striatum extend projections to the SVZ. Optogenetic stimulation of glutamatergic activity in the striatum releases glutamate into SVZ. The glutamate release increased proliferation of SVZ neuroblasts, mediated by AMPAR activation. Stimulation of striatal glutamatergic activity augments neuroblasts proliferation, survival, and migration after stroke. The striatum promoted neurogenesis improves functional recovery after stroke.