Acute stress diminishes M-current contributing to elevated activity of hypothalamic-pituitary-adrenal axis

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• 作者：Jing-Jing Zhou^a ; ^b ; Yonggang Gao^c ; Therese A. Kosten^d ; Zongmao Zhao^e ; ^{zzm69@163.com} ; De-Pei Li^a ; ^{dpli@mdanderson.org}
• 关键词：Acute stress ; Corticosterone ; Paraventricular nucleus ; Voltage dependent K+ channel ; AMPK
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：114
• 期：Complete
• 页码：67-76
• 全文大小：2232 K
• 卷排序：114

文摘

Acute restraint stress blunted M-current activity in PVN-CRH neurons. Acute restraint stress reduced the expression level of membrane fraction of Kv7.3 subunit. Acute restraint stress increased AMPK activity in the PVN tissue. Increased AMPK activity is responsible for acute stress-induced reduction of M-current and membrane Kv7.3 protein levels.