Increased methylation of repetitive elements and DNA repair genes is associated with higher DNA oxidation in children in an urbanized, industrial environment

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• 作者：Isabel Alvarado-Cruz^a ; ^{mialvarado@cinvestav.mx} ; Marco Sá ; nchez-Guerra^a ; ¹ ; ^{msanchez@hsph.harvard.edu} ; Leticia Herná ; ndez-Cadena^c ; ^{lhcadena@insp.mx} ; Andrea De Vizcaya-Ruiz^a ; ^{avizcaya@cinvestav.mx} ; Violeta Mugica^d ; ^{vma@correo.azc.uam.mx} ; Nadia Azenet Pelallo-Martí ; nez^a ; ² ; ^{na_pelallom@yahoo.com.mx} ; Marí ; a de Jesú ; s Solí ; s-Heredia^a ; ^{maria.solis@cinvestav.mx} ; Hyang-Min Byun^b ; ³ ; ^{Hyang-Min.Byun@newcastle.ac.uk} ; Andrea Baccarelli^b ; ⁴ ; ^{abaccare@hsph.harvard.edu} ; Betzabet Quintanilla-Vega^a ; ^{mquintan@cinvestav.mx}
• 关键词：DNA methylation ; DNA repair ; PM exposure ; Children&rsquo ; s health ; Genetic damage
• 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：813
• 期：Complete
• 页码：27-36
• 全文大小：1109 K
• 卷排序：813

文摘

Exposure to PM10 is associated with genetic damage and DNA methylation in children. Hypermethylation of DNA-repair genes can contribute to DNA damage. Benzo[b]fluoranthene content in PM10 resulted in an increase in LINE1 methylation. Methylation of DNA repair genes was increased by PAHs and metals adsorbed in PM10. Methylation of PARP1 promoter was correlated with an increased oxidative DNA damage.