Mexican Arnica (Heterotheca inuloides Cass. Asteraceae: Astereae): Ethnomedical uses, chemical constituents and biological properties

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• 作者：José ; Luis Rodrí ; guez-Chá ; vez^a ; Veró ; nica Egas^a ; Edelmira Linares^b ; Robert Bye^b ; Tzasna Herná ; ndez^c ; Francisco J. Espinosa-Garcí ; a^d ; Guillermo Delgado^a ; ^{delgado@unam.mx}
• 关键词：ABTS ; 2 ; 2&prime ; -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) ; Akt/PKB ; protein kinase B ; BRL15572 ; 3-(4-(4-chlorophenyl)piperazin-1-yl)&minus ; 1 ; 1-diphenyl-2-propanol ; CCl4 ; carbon tetrachloride ; C. elegans ; Caernorhabditis elegans ; COE-EDQM ; Council of Europe-European Directorate for the Quality of Medicines ; COX ; cyclooxygenase or prostaglandin-endoperoxide synthase ; DPPH ; 2 ; 2-diphenyl-1-picrylhydrazyl ; EIMS ; electron ionization mass spectroscopy ; FeSO4 ; ferrous sulfate ; fMLP/PAF ; N-Form
• 刊名：Journal of Ethnopharmacology
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：195
• 期：Complete
• 页码：39-63
• 全文大小：2546 K
• 卷排序：195

文摘

Heterotheca inuloides Cass. (Asteraceae) has been traditionally used to treat a wide range of diseases in Mexico in the treatment of rheumatism, topical skin inflammation, muscular pain colic, and other painful conditions associated with inflammatory processes, additionally has been used to treat dental diseases, and gastrointestinal disorders. This species has also been used for the treatment of cancer and diabetes. This review provides up-to-date information on the botanical characterization, traditional uses, chemical constituents, as well as the biolological activities of H. inuloides.Material and methodsA literature search was conducted by analyzing the published scientific material. Information related to H. inuloides was collected from various primary information sources, including books, published articles in peer-reviewed journals, monographs, theses and government survey reports. The electronic search of bibliographic information was gathered from accepted scientific databases such as Scienfinder, ISI Web of Science, Scielo, LILACS, Redalyc, Pubmed, SCOPUS and Google Scholar.ResultsTo date, more than 140 compounds have been identified from H. inuloides, including cadinane sesquiterpenes, flavonoids, phytosterols, triterpenes, benzoic acid derivatives, and other types of compounds. Many biological properties associated with H. inuloides. Many studies have shown that the extracts and some compounds isolated from this plant exhibit a broad spectrum of biological activities such as antioxidant, antitumor, anti-inflammatory, cytotoxic, and chelating activities, as well as insecticidal and phytotoxic activity. To date, reports on the toxicity of H. inuloides are limited.ConclusionsA comprehensive analysis of the literature obtained through the above-mentioned sources confirmed that ethnomedical uses of H. inuloides have been recorded in Mexico to treat rheumatism, pain, and conditions associated with inflammatory processes. Pharmacological studies have demonstrated the activity of certain compounds associated with the traditional use of the plant such as the anti-inflammatory and cytotoxic activities of the species. The available literature showed that cadinene sesquiterpenes are the major bioactive components of H. inuloides with potential pharmacological activities. Further investigations are needed to fully understand the mode of action of the major active constituents.