Mitochondrial functions of THP-1 monocytes following the exposure to selected natural compounds

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• 作者：Nadin Schultze^a ; ^{nadin.schultze@uni-greifswald.de} ; Heike Wanka^b ; Paula Zwicker^a ; Ulrike Lindequist^a ; Beate Haertel^a
• 关键词：CBD ; cannabidiol ; CsA ; cyclosporine A ; DON ; deoxynivalenol ; ETC ; electron transport chain ; FCCP ; carbonyl cyanide-4 (trifluoromethoxy) phenylhydrazone ; IC10 ; inhibitory concentration 10 ; IC50 ; inhibitory concentration 50 ; MTT ; 3-(4 ; 5-dimethylthiazolyl-2)-2 ; 5-diphenyltetrazolium bromide ; OCR ; oxygen consumption rate ; RSC ; respiratory spare capacity
• 刊名：Toxicology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：377
• 期：Complete
• 页码：57-63
• 全文大小：1204 K
• 卷排序：377

文摘

CsA and CBD impair mitochondrial functions in THP-1 cells using XF 96 technology. Both compounds increase intracellular ROS and induce apoptosis. DON has no major influence on mitochondrial functions, iROS and apoptosis. Reduced respiratory spare capacity seems to be associated with iROS and apoptosis. Respiratory spare capacity might be a good indicator for cell viability.