Lithium increases synaptic GluA2 in hippocampal neurons by elevating the δ-catenin protein

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• 作者：Mobeen Farooq^a ; ¹ ; ² ; Seonil Kim^a ; ¹ ; ³ ; Sunny Patel^a ; ¹ ; Latika Khatri^a ; Takuya Hikima^b ; Margaret E. Rice^b ; Edward B. Ziff^a ; ^{edward.ziff@nyumc.org}
• 关键词：Lithium ; δ-Catenin ; GRIP ; AMPA receptor ; GluA2 ; PICK1
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：426-433
• 全文大小：1476 K
• 卷排序：113

文摘

δ-catenin links cadherins to GRIP, a GluA2 AMPA receptor subunit synaptic anchor. Mutation of δ-catenin induces neurological disorders including autism. Li+ is used to treat bipolar disorder, but the mechanism is unknown. Li+ elevates synaptic δ-catenin and associated GRIP and GluA2 in neuronal cultures. Li+ increases synaptic GluA2 in vivo, suggesting a therapeutic mechanism of action.