The inhibition of spinal synaptic plasticity mediated by activation of AMP-activated protein kinase signaling alleviates the acute pain induced by oxaliplatin

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• 作者：Yun-Zhi Ling^a ; ¹ ; Zhen-Yu Li^b ; ¹ ; Han-Dong Ou-Yang^c ; ¹ ; Chao Ma^d ; Shao-Ling Wu^d ; Jia-You Wei^a ; Huan-Huan Ding^a ; Xiao-Long Zhang^a ; Meng Liu^a ; Cui-Cui Liu^d ; ^{lucyliucuicui@126.com} ; Zhen-Zhen Huang^a ; ^{Huangzhzh3@mail.sysu.edu.cn} ; Wen-Jun Xin^a
• 关键词：AMPKα ; LTP ; mTOR/p70S6K signal pathway ; Oxaliplatin ; Acute pain
• 刊名：Experimental Neurology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：288
• 期：Complete
• 页码：85-93
• 全文大小：2516 K
• 卷排序：288

文摘

The decreased AMPKα via enhancing spinal synaptic plasticity contributed to the acute pain following single intraperitoneal injection of oxaliplatin. Activation of mTOR/p70S6K signal pathway contributed to acute pain induced by low concentration of oxaliplatin entering CNS. The decreased AMPKα via negatively regulating the mTOR/p70S6K signal pathway mediated the acute pain induced by oxaliplatin.