Fear conditioning selectively disrupts noradrenergic facilitation of GABAergic inhibition in the basolateral amygdala

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• 作者：M.J. Skelly ; O.J. Ariwodola ; J.L. Weiner ; ^{jweiner@wakehealth.edu}
• 关键词：Fear-potentiated startle ; GABA release ; α1 Adrenoreceptor ; β3 Adrenoreceptor ; β1/2 Adrenoreceptor ; Norepinephrine
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：231-240
• 全文大小：1475 K
• 卷排序：113

文摘

Basolateral amygdala (BLA) GABAergic signaling is reduced after fear conditioning. Fear conditioning reduces noradrenergic facilitation of BLA GABAergic signaling. Noradrenergic facilitation of excitatory signaling is not altered by fear learning. Fear conditioning disrupts the excitatory/inhibitory balance of BLA noradrenaline.