Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells

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• 作者：Xinhui Wang^a ; LaNita Nichols^a ; Elizabeth A. Grunz-Borgmann^a ; Zhe Sun^a ; ^b ; Gerald A. Meininger^a ; ^b ; Timothy L. Domeier^a ; Christopher P. Baines^b ; ^c ; Alan R. Parrish^a ; ^{parrishar@health.missouri.edu}
• 关键词：α-Catenin ; Actin ; Aging ; Apoptosis ; Fascin2 ; Mitochondria
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：266
• 期：Complete
• 页码：56-64
• 全文大小：2111 K
• 卷排序：266

文摘

Cisplatin induces loss of fascin2 protein expression in vitro and in vivo. Fascin2 is regulated, in part, by α(E)-catenin. Knockdown of fascin2 increases susceptibility to cisplatin nephrotoxicity in vitro. Overexpression of fascin2 is renoprotective against cisplatin injury in vitro.