4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells

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• 作者：Peng Duan^a ; ^b ; Chunhui Hu^c ; Chao Quan^a ; Tingting Yu^a ; Wenting Huang^a ; Wei Chen^a ; Sha Tang^a ; Yuqin Shi^d ; Francis L. Martin^e ; Kedi Yang^a ; ^{yangkd@mails.tjmu.edu.cn}
• 关键词：4-nonylphenol ; Sertoli cells ; Autophagy ; AMPK ; mTOR-p70S6K/4EBP1
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：267
• 期：Complete
• 页码：21-31
• 全文大小：4141 K
• 卷排序：267

文摘

4-Nonylphenol promoted Sertoli cell autophagy and modulated the AMPK-mTOR-p70S6K/4EBP1 signaling pathways in rat testis. 4-Nonylphenol induced autophagy via activating AMPK signaling in Sertoli cells. 4-Nonylphenol inhibited mTOR-p70S6K/4EBP1 activity through AMPK activation in Sertoli cells.