Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism

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• 作者：Lars Stechemesser¹ ; Sebastian K. Eder¹ ; ² ; Andrej Wagner¹ ; Wolfgang Patsch³ ; Alexandra Feldman¹ ; ² ; Michael Strasser¹ ; Simon Auer⁴ ; David Niederseer⁵ ; ⁶ ; Ursula Huber-Schö ; nauer⁵ ; Bernhard Paulweber¹ ; Stephan Zandanell¹ ; Sandra Ruhaltinger¹ ; Daniel Weghuber² ; Elisabeth Haschke-Becher⁴ ; Christoph Grabmer⁷ ; Eva Rohde⁷ ; Christian Datz² ; ⁵ ; Thomas K. Felder² ; ⁴ ; ⁸ ; Elmar Aigner¹ ; ² ; ⁸ ; ^{e.aigner@salk.at}
• 关键词：Metabolomics ; Hyperferritinemia ; Iron overload ; Metabolic syndrome ; Glucose
• 刊名：Molecular Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：6
• 期：1
• 页码：38-47
• 全文大小：918 K
• 卷排序：6

文摘

This metabolomic study focuses on pathways linking iron status to insulin resistance. Metabolomic differences in Metabolic Syndrome with/without iron overload are shown. Phlebotomy changes methionine, glutamate and long-chain phosphatidylcholines levels. Phosphatidylcholines are involved in the interaction of iron and glucose homeostasis.