Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease

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• 作者：Christopher A Brown^a ; Nathan F Johnson^b ; Amelia J Anderson-Mooney^c ; Gregory A Jicha^c ; ^d ; Leslie M Shaw^g ; John Q Trojanowski^g ; Linda J Van Eldik^a ; ^d ; Frederick A Schmitt^c ; ^d ; ^e ; Charles D Smith^c ; ^d ; ^f ; Brian T Gold^a ; ^d ; ^f ; ^{brian.gold@uky.edu}
• 关键词：Fornix ; Diffusion tensor imaging ; Aging ; Aβ amyloid ; Tau
• 刊名：NeuroImage: Clinical
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：13
• 期：Complete
• 页码：106-115
• 全文大小：1095 K
• 卷排序：13

文摘

A new merged, younger-older DTI template of the fornix was developed. Template anatomical validity, sensitivity and specificity were demonstrated. Template metrics correlate with Alzheimer's pathology. The new fornix template is an appropriate tool for aging and Alzheimer's research.