Human albumin attenuates excessive innate immunity via inhibition of microglial Mincle/Syk signaling in subarachnoid hemorrhage

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• 作者：Yi Xie^a ; ¹ ; Hongquan Guo^a ; ¹ ; Liumin Wang^a ; ¹ ; Lili Xu^a ; Xiaohao Zhang^b ; Linjie Yu^c ; Qian Liu^a ; Yunzi Li^a ; Nana Zhao^a ; Nan Zhao^a ; Ruidong Ye^a ; ^{yeruid@gmail.com} ; Xinfeng Liu^a ; ^{xfliu2@vip.163.com}
• 关键词：Subarachnoid hemorrhage ; Albumin ; Microglia ; Mincle
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：346-360
• 全文大小：4797 K
• 卷排序：60

文摘

Subarachnoid hemorrhage activates cerebral innate immunity by Mincle/Syk pathway. Albumin can abolish immune responses by directly binding microglial Mincle receptor after subarachnoid hemorrhage. Neuronal necroptosis product, SAP130, launches the stimulation of Mincle on microglial cells. Albumin supplementation can deactivate SAP130-induced microglial motivation.