STAT1 as a downstream mediator of ERK signaling contributes to bone cancer pain by regulating MHC II expression in spinal microglia

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• 作者：Zhenpeng Song^a ; ^b ; ¹ ; Bingrui Xiong^a ; ¹ ; Hua Zheng^a ; Anne Manyande^d ; Xuehai Guan^e ; Fei Cao^a ; Lifang Ren^a ; Yaqun Zhou^a ; Dawei Ye^c ; ^{dy0711@gmail.com} ; Yuke Tian^a ; ^{yktian@tjh.tjmu.edu.cn}
• 关键词：Bone cancer pain ; Microglia ; Major histocompatibility complex class II ; ERK ; STAT1
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：161-173
• 全文大小：4483 K
• 卷排序：60

文摘

MHC II was expressed on activated microglia in the spinal cord dorsal horn of BCP rats. STAT1 is a major mediator in modulating the expression of MHC II in microglia. Phosphorylation of STAT1 is regulated by ERK signaling under BCP condition.