The role of PTEN in regulation of hepatic macrophages activation and function in progression and reversal of liver fibrosis

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• 作者：Yahui Cheng ; Yuanyao Tian ; Jialu Xia ; Xiaoqin Wu ; Yang Yang ; Xiaofeng Li ; Cheng Huang ; Xiaoming Meng ; Taotao Ma ; Jun Li ; ^{lj@ahmu.edu.cn}
• 关键词：PTEN ; Macrophges differentiation ; Kupffer cells ; Hepatic fibrosis ; Reversal fibrosis ; PI3K/Akt/STAT
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：317
• 期：Complete
• 页码：51-62
• 全文大小：2559 K
• 卷排序：317

文摘

CCl4 treatment triggered a mixed M1/M2 macrophage phenotype in fibrosis. Lower expression of PTEN in murine M2 macrophages in vivo and vitro. PTEN modulates M2 macrophages activation via PI3K/Akt/STAT6 signaling. Provide a new cellular target modulate macrophage mediated hepatic fibrosis.