Didymin induces apoptosis through mitochondrial dysfunction and up-regulation of RKIP in human hepatoma cells

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• 作者：Jinbin Wei^b ; ¹ ; Quanfang Huang^a ; ¹ ; Facheng Bai^b ; Jun Lin^b ; Jinlan Nie^b ; Shengjuan Lu^b ; Chunyuang Lu^b ; Renbin Huang^b ; Zhongpeng Lu^a ; ^c ; Xing Lin^b ; ^{gxLx60@163.com}
• 关键词：Didymin ; Mitochondrial dysfunction ; ERK/MAPK pathway ; PI3K/Akt pathway ; RKIP
• 刊名：Chemico-Biological Interactions
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：261
• 期：Complete
• 页码：118-126
• 全文大小：2369 K
• 卷排序：261

文摘

Didymin inhibits HepG2 cell growth and induces apoptosis. Didymin induces mitochondrial dysfunction. Didymin inhibits MAPK and PI3K/Akt pathways by increasing RKIP level.