Association of maternal angiotensinogen gene M235T polymorphism with preeclampsia in South India: A tertiary care hospital based case-control study

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• 作者：Krishnaveni Chengalvala^a ; Pushpa Kotur^b ; Mitesh Shetty^c ; Praveen Kumar^c ; Jagadish T.V.^c ; Nagarjuna Sivaraj^c ; Sharath Balakrishna^c ; ^{sharath@sduu.ac.in}
• 关键词：Preeclampsia ; Polymorphism ; Angiotensinogen Gene ; India
• 刊名：Meta Gene
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：11
• 期：Complete
• 页码：108-110
• 全文大小：188 K
• 卷排序：11

文摘

M235T polymorphism (rs699) in angiotensinogen (AGT) gene is associated with the risk of developing preeclampsia. This case-control study examines the profile of AGT M235T polymorphism in preeclamptic and normotensive pregnancies in a South Indian population.MethodsA total of 300 women comprising of 150 preeclamptic pregnancies and an equal number of normotensive pregnancies were enrolled in the study. AGT M235T polymorphism was determined by PCR-RFLP technique. Differences in the distribution of alleles and genotypes among cases and controls was evaluated for statistical significance by means of contingency table.ResultsThe presence of AGT 235 T allele was found to be associated with the increased risk of developing preeclampsia [P = 0.003, odds ratio = 1.69 (95% CI: 1.20–2.38)]. At the genotype level, the odds ratio for the risk of PE was 2.52 (95% CI: 1.25–5.07) and 1.67 (95% CI: 1.05–2.63) in the dominant and recessive models respectively.ConclusionsOur results support the conclusion that AGT M235T polymorphism is associated with increased risk of developing preeclampsia in the South Indian population. This is the first study to report a positive association between AGT M235T polymorphism and preeclampsia in the Indian population.