Association of mitochondrial DNA haplogroups with elite athletic status in Iranian population

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• 作者：Sareh Arjmand^a ; ^b ; ^{s_arjmand@sbu.ac.ir} ; Neda Khaledi^c ; Rana Fayazmilani^d ; Abbas Sahebghadam Lotfi^b ; Hossein Tavana^e
• 关键词：mtDNA ; mitochondrial DNA ; SNP ; single nucleotide polymorphism ; D-loop ; displacement loop ; PCR ; polymerase chain reaction ; rCRS ; revised Cambridge Reference Sequence ; ETC ; electron transport chain ; ROS ; reactive oxygen species ; VO2max ; maximal oxygen uptake
• 刊名：Meta Gene
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：11
• 期：Complete
• 页码：81-84
• 全文大小：320 K
• 卷排序：11

文摘

Increasing evidences suggest that certain variations in the control region of mitochondrial DNA (mtDNA) are associated with physical performance levels of individuals. The aim of the present study was to assess whether mitochondrial haplogroups are associated with elite athlete status in Iranian population. The mtDNA haplogroups of 100 Iranian athletes and 100 healthy, non-athletic individuals were genotyped. Significant differences were observed for haplogroups U and J, which were under- and over-represented in the elite athletes group. The results show that mtDNA haplogroups and their related phenotypic expression correlate with the physical performance.