Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury

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• 作者：Tao Li¹ ; ² ; Zhen Zhang² ; ⁴ ; Stephen C. Kolwicz Jr.² ; Lauren Abell² ; Nathan D. Roe² ; Maengjo Kim² ; Bo Zhou² ; Yang Cao² ; Julia Ritterhoff² ; Haiwei Gu² ; Daniel Raftery² ; Haipeng Sun³ ; Rong Tian² ; ⁵ ; ^{rongtian@uw.edu}
• 关键词：branched-chain amino acids ; cardiac metabolism ; glucose ; pyruvate dehydrogenase ; ischemia-reperfusion ; mitochondria ; N-glcNacation
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：374-385
• 全文大小：3795 K
• 卷排序：25

文摘

Branched-chain amino acid (BCAA) catabolism regulates glucose metabolism in the heart High levels of BCAAs selectively disrupt mitochondrial pyruvate utilization Downregulation of HBP by chronic accumulation of BCAAs inactivates PDH Defective BCAA catabolism sensitizes the heart to ischemia-reperfusion insult