Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans

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• 作者：Denis P. Blondin¹ ; Fré ; dé ; rique Frisch¹ ; Serge Phoenix¹ ; ⁴ ; Brigitte Gué ; rin⁴ ; É ; ric E. Turcotte⁴ ; Franç ; ois Haman³ ; Denis Richard² ; André ; C. Carpentier¹ ; ⁵ ; ^{andre.carpentier@usherbrooke.ca}
• 关键词：lipolysis ; energy metabolism ; brown adipose tissue ; positron emission tomography ; shivering ; thermogenesis ; intracellular triglyceride lipolysis ; nonesterified fatty acid metabolism
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：438-447
• 全文大小：2117 K
• 卷排序：25

文摘

Niacin-induced inhibition of lipolysis abolishes mobilization of lipids in BAT Inhibition of adipose tissue lipolysis abolishes cold-induced BAT thermogenesis Inhibition of BAT lipolysis did not abolish cold-stimulated BAT perfusion Inhibiting BAT thermogenesis was compensated by commensurate increase in shivering