Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting

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• 作者：Maximilian Hatting¹ ; ² ; Amy K. Rines¹ ; Chi Luo¹ ; Mitsuhisa Tabata¹ ; Kfir Sharabi¹ ; Jessica A. Hall¹ ; Francisco Verdeguer¹ ; Christian Trautwein² ; Pere Puigserver¹ ; ³ ; ^{pere_puigserver@dfci.harvard.edu}
• 关键词：CLK2 ; intermittent fasting ; brown fat ; high-fat diet ; diet-induced thermogenesis ; refeeding ; UCP1 ; p-CREB ; PP2A
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：428-437
• 全文大小：2553 K
• 卷排序：25

文摘

Loss of adipose CLK2 exacerbates obesity during high-fat time-restricted feeding CLK2 knockout decreases feeding-induced energy expenditure and UCP1 in brown fat CREB activity is attenuated by CLK2 loss via enhanced CREB dephosphorylation PP2A inhibition rescues CREB dephosphorylation in CLK2 knockout brown adipocytes