Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats

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• 作者：Mohammed K. Hankir¹ ; ¹⁰ ; Florian Seyfried² ; ¹⁰ ; Constantin A. Hintschich¹ ; ¹⁰ ; Thi-Ai Diep³ ; Karen Kleberg⁴ ; Mathias Kranz⁵ ; Winnie Deuther-Conrad⁵ ; Luis A. Tellez⁸ ; Michael Rullmann⁶ ; Marianne Patt⁶ ; Jens Teichert⁷ ; Swen Hesse¹ ; ⁶ ; Osama Sabri¹ ; ⁶ ; Peter Brust⁵ ; Harald S. Hansen⁴ ; Ivan E. de Araujo⁸ ; Ute Krü ; gel⁹ ; ^{ute.kruegel@medizin.uni-leipzig.de} ; Wiebke K. Fenske¹ ; ¹¹ ; ^{wiebkekristin.fenske@medizin.uni-leipzig.de}
• 关键词：gastric bypass surgery ; fat appetite ; altered nutrient preference ; dopamine system ; D1R signaling ; OEA ; PPAR-alpha ; [11C] SCH 23390
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：335-344
• 全文大小：2366 K
• 卷排序：25

文摘

RYGB increases meal-stimulated intestinal OEA synthesis and striatal DA release Enhanced striatal DA responses caused by RYGB require an intact vagus nerve RYGB upregulates striatal D1Rs specifically under HF feeding conditions RYGB effects on fat appetite require intact gut PPARα and striatal D1R signaling