Serine Is an Essential Metabolite for Effector T Cell Expansion

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• 作者：Eric H. Ma¹ ; ² ; Glenn Bantug³ ; Takla Griss¹ ; ² ; Stephanie Condotta⁴ ; ⁵ ; Radia M. Johnson¹ ; Bozena Samborska¹ ; ² ; Nello Mainolfi⁶ ; Vipin Suri⁶ ; Hannah Guak¹ ; ² ; Maria L. Balmer³ ; Mark J. Verway¹ ; ² ; Thomas C. Raissi¹ ; ² ; Harmony Tsui¹ ; ² ; Giselle Boukhaled¹ ; ² ; Sofia Henriques da Costa⁷ ; Christian Frezza⁷ ; Connie M. Krawczyk¹ ; ² ; ⁴ ; Adam Friedman⁶ ; Mark Manfredi⁶ ; Martin J. Richer⁴ ; ⁵ ; Christoph Hess³ ; Russell G. Jones¹ ; ² ; ⁸ ; ^{russell.jones@mcgill.ca}
• 关键词：serine ; metabolism ; T cell ; immunometabolism ; metabolic reprogramming ; serine biosynthesis ; glycolysis ; Shmt ; Phgdh ; immunotherapy
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：345-357
• 全文大小：3863 K
• 卷排序：25

文摘

Enzymes of SGOC metabolism are upregulated upon T cell activation Serine is required for optimal T cell proliferation in vitro and in vivo Serine supports de novo purine biosynthesis in proliferating T cells One-carbon units from formate can bypass serine starvation