FGF21 Is an Exocrine Pancreas Secretagogue

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• 作者：Katie C. Coate¹ ; ⁴ ; ⁵ ; Genaro Hernandez¹ ; ⁴ ; Curtis A. Thorne¹ ; Shengyi Sun¹ ; Thao D.V. Le¹ ; Kevin Vale¹ ; Steven A. Kliewer¹ ; ² ; ^{steven.kliewer@utsouthwestern.edu} ; David J. Mangelsdorf¹ ; ³ ; ⁶ ; ^{davo.mango@utsouthwestern.edu}
• 关键词：FGF21 ; secretagogue ; exocrine pancreas ; CCK ; proteostasis ; β-Klotho ; acinar cell ; pancreatitis ; calcium signaling ; secretion
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：472-480
• 全文大小：2411 K
• 卷排序：25

文摘

FGF21 stimulates digestive enzyme secretion and pancreatic juice flow FGF21 protects the exocrine pancreas from proteotoxic stress The effects of FGF21 on secretion are mediated by its action on the acinar cell FGF21 triggers calcium release via an FGFR/β-Klotho/PLCγ/IP3R signaling pathway