The influence of ¦Ã irradiation and ethylene oxide treatment on the release characteristics of biodegradable poly(lactide-co-glycolide) composites

详细信息    查看全文

• 作者：Chao-Ying Hsiao^a ; Shih-Jung Liu^a ; ^{shihjung@mail.cgu.edu.tw} ; Steve Wen-Neng Ueng^b ; Err-Cheng Chan^c
• 关键词：Biodegradable composites ; Sterilization ; ¦Ã irradiation ; Ethylene oxide ; Release characteristics ; Vancomycin
• 刊名：Polymer Degradation and Stability
• 出版年：2012
• 出版时间：May, 2012
• 年：2012
• 卷：97
• 期：5
• 页码：715-720
• 全文大小：564 K

文摘

This study evaluated the influence of ¦Ã irradiation and ethylene oxide sterilization on the release characteristics of vancomycin from biodegradable poly[(d,l)-lactide-co-glycolide] (PLGA) composite beads. Biodegradable composites incorporating vancomycin were prepared using a compression-sintering method. They were then subjected to various doses of ¦Ã irradiation and ethylene oxide treatment. After sterilization, the composites were placed in 3?ml of phosphate buffered saline and incubated at 37?¡ãC. An in-vitro elution method and a high-performance liquid chromatography (HPLC) were used to characterize the release rates of the antibiotics over a 30-day period. A bacterial inhibitory test was also employed to examine the bioactivity of released antibiotics. All sterilizations were found to result in a decrease of the crystallinity of the polymeric materials, as well as the total release period of antibiotics. The ethylene oxide treatment led to a significant change of the morphology of the composites. Furthermore, the results suggest that the biodegradable composites can release high concentrations of antibiotics (well above the minimum inhibitory concentration) in-vitro for up to 28 days after ¦Ã irradiation of less than 25?kGy.